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Last updated: 2016/10/23
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KCNN2 polyclonal antibody

  • Catalog # : PAB17822
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of KCNN2.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human KCNN2.
  • Sequence:
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 63.8, 26.3
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:64000)
    Western Blot (0.3-1 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • KCNN2 polyclonal antibody (Cat # PAB17822) (0.3 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • KCNN2 polyclonal antibody (Cat # PAB17822)(3.8 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3781
  • Protein Accession#:
  • NP_067627.2;NP_740721.1
  • Gene Name:
  • KCNN2
  • Gene Alias:
  • KCa2.2,SK2,SKCA2,hSK2
  • Gene Description:
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
  • Gene Summary:
  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • apamin-sensitive small-conductance Ca2+-activated potassium channel,small conductance calcium-activated potassium channel protein 2
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