Products

Western Blot (Tissue lysate)

KCNN2 polyclonal antibody (Cat # PAB17822) (0.3 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

KCNN2 polyclonal antibody (Cat # PAB17822)(3.8 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

3781

Protein Accession#

NP_067627.2;NP_740721.1

Gene Name

KCNN2

Gene Alias

KCa2.2, SK2, SKCA2, hSK2

Gene Description

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Omim ID

605879

Gene Ontology

Hyperlink

Gene Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

apamin-sensitive small-conductance Ca2+-activated potassium channel|small conductance calcium-activated potassium channel protein 2