PLA2R1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PLA2R1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PLA2R1.
Sequence
C-EKKKDTPKQHGT
Host
Goat
Theoretical MW (kDa)
169, 153
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PLA2R1 polyclonal antibody (Cat # PAB17818) (1 ug/mL) staining of human ileum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLA2R1
Entrez GeneID
22925Protein Accession#
NP_031392.3;NP_001007268.1Gene Name
PLA2R1
Gene Alias
CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
Gene Description
phospholipase A2 receptor 1, 180kDa
Omim ID
604939Gene Ontology
HyperlinkGene Summary
Secretory phospholipases A2 (PLA2s) have been purified from a variety of mammalian tissues as well as from insect and snake venoms. The prototype group I PLA2, the pancreatic PLA2 (PLA2G1B; MIM 172410), is involved in digestion, smooth muscle contraction, and cell proliferation. The prototype group II PLA2, the inflammatory-type PLA2 (PLA2G2A; MIM 172411), is involved in inflammatory conditions and is upregulated by proinflammatory cytokines like tumor necrosis factor (TNF; MIM 191160) and interleukin-1 (e.g., IL1B; MIM 147720). Differential toxicity of snake venom Pla2 appears to be linked to a variety of high-affinity receptors in different organs (Ancian et al., 1995 [PubMed 7721806]).[supplied by OMIM
Other Designations
phospholipase A2 receptor 1
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Interactome
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Disease
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