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Last updated: 2017/11/19
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KIR2DL5B polyclonal antibody

  • Catalog # : PAB17754
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of KIR2DL5B.
  • Immunogen:
  • A synthetic peptide corresponding to internal of human KIR2DL5B.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody detects endogenous levels of total KIR2DL5B protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Immunofluorescence (1:500-1:1000)
    ELISA (1:40000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence analysis of A-549 cells, using KIR2DL5B polyclonal antibody (Cat # PAB17754).
    Peptide "+" means "with peptide blocking".
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Gene Name:
  • KIR2DL5B
  • Gene Alias:
  • KIR2DL5,KIR2DL5.2,KIR2DLX
  • Gene Description:
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
  • Gene Summary:
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
  • Other Designations:
  • killer cell Ig-like receptor
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