Western blot analysis of extracts from COLO cells (Lane 1), HUVEC cells (Lane 2 and lane 4) and MCF-7 cells (Lane 3), using GRB14 polyclonal antibody (Cat # PAB17735). Peptide "+" means "with peptide blocking".
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq