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KDELR3 polyclonal antibody

  • Catalog # : PAB17715
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of KDELR3.
  • Immunogen:
  • A synthetic peptide corresponding to internal of human KDELR3.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody detects endogenous levels of total KDELR3 protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    ELISA (1:20000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extracts from NIH/3T3 cells, using KDELR3 polyclonal antibody (Cat # PAB17715).
    Peptide "+" means "with peptide blocking".
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • KDELR3
  • Gene Alias:
  • ERD2L3
  • Gene Description:
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
  • Gene Summary:
  • Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. [provided by RefSeq
  • Other Designations:
  • KDEL receptor 3,OTTHUMP00000028924
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