Western blot analysis of extracts from HeLa cells (Lane 1), A-549 cells (Lane 2) and HUVEC cells (Lane 3 and lane 4), using PNPLA8 polyclonal antibody (Cat # PAB17642). Peptide "+" means "with peptide blocking".
Phospholipase A2 catalyzes cleavage of fatty acids from phospholipids, thereby regulating membrane physical properties and the release of lipid second messengers and growth factors. Phospholipase A2 activity also modulates cellular growth programs, inflammation, and ion channel function (Mancuso et al., 2000 [PubMed 10744668]).[supplied by OMIM