Western blot analysis of extracts from HeLa cells (Lane 1), 293 cells (lane 2 and lane 4) and HUVEC cells (Lane 3), using AASS polyclonal antibody (Cat # PAB17603). Peptide "+" means "with peptide blocking".
This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq