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Last updated: 2016/12/11
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MLH3 polyclonal antibody

  • Catalog # : PAB17549
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of MLH3.
  • Immunogen:
  • A synthetic peptide corresponding to internal of human MLH3.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody detects endogenous levels of total MLH3 protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    ELISA (1:40000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extracts from K-562 cells (Lane 1 and lane 3) and HT-29 cells (Lane 2), using MLH3 polyclonal antibody (Cat # PAB17549).
    Peptide "+" means "with peptide blocking".
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • MLH3
  • Gene Alias:
  • HNPCC7,MGC138372
  • Gene Description:
  • mutL homolog 3 (E. coli)
  • Gene Summary:
  • This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq
  • Other Designations:
  • DNA mismatch repair protein MLH3,mutL homolog 3
  • Gene Pathway
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