CYP2C19 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP2C19.
Immunogen
A synthetic peptide corresponding to C-terminus of human CYP2C19.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total CYP2C19 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells, using CYP2C19 polyclonal antibody (Cat # PAB17527).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP2C19
Entrez GeneID
1557Protein Accession#
P33261Gene Name
CYP2C19
Gene Alias
CPCJ, CYP2C, P450C2C, P450IIC19
Gene Description
cytochrome P450, family 2, subfamily C, polypeptide 19
Omim ID
124020Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq
Other Designations
OTTHUMP00000020132|OTTHUMP00000059588|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|flavoprotein-linked monooxygenase|mephenytoin 4'-hydroxylase|microsomal monooxygenase|xenobi
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