STAM polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The STAM polyclonal antibody (Cat # PAB1751) is used in Western blot to detect STAM in mouse liver tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAM polyclonal antibody (Cat # PAB1751) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STAM.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human STAM.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The STAM polyclonal antibody (Cat # PAB1751) is used in Western blot to detect STAM in mouse liver tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAM polyclonal antibody (Cat # PAB1751) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — STAM
Entrez GeneID
8027Protein Accession#
Q92783Gene Name
STAM
Gene Alias
DKFZp686J2352, STAM1
Gene Description
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Omim ID
601899Gene Ontology
HyperlinkGene Summary
This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein. [provided by RefSeq
Other Designations
OTTHUMP00000019237|signal transducing adaptor molecule 1
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Interactome
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Pathway
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Disease
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