PSMD4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PSMD4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 300-328 of human PSMD4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PSMD4 polyclonal antibody (Cat # PAB1741) is used in Western blot to detect PSMD4 in Jurkat cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSMD4
Entrez GeneID
5710Protein Accession#
P55036Gene Name
PSMD4
Gene Alias
AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5
Gene Description
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Omim ID
601648Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq
Other Designations
26S protease subunit S5a|26S proteasome non-ATPase regulatory subunit 4|OTTHUMP00000014286|OTTHUMP00000059963|S5a/antisecretory factor protein|angiocidin|antisecretory factor 1|multiubiquitin chain binding protein|proteasome 26S non-ATPase subunit 4
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Interactome
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Pathway
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Publication Reference
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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM.
Biochemistry 2002 Feb; 41(6):1767.
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Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.
Kawahara H, Kasahara M, Nishiyama A, Ohsumi K, Goto T, Kishimoto T, Saeki Y, Yokosawa H, Shimbara N, Murata S, Chiba T, Suzuki K, Tanaka K.
The EMBO Journal 2000 Aug; 19(15):41444.
Application:WB-Ti, Mouse, Embryo, Brain.
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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.
Tanahashi N, Murakami Y, Minami Y, Shimbara N, Hendil KB, Tanaka K.
The Journal of Biological Chemistry 2000 May; 275(19):14336.
Application:WB-Ce, Human, HeLa cells.
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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
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