CERKL polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from A-549 cells, using CERKL polyclonal antibody (Cat # PAB17393).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CERKL.
Immunogen
A synthetic peptide corresponding to internal of human CERKL.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total CERKL protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from A-549 cells, using CERKL polyclonal antibody (Cat # PAB17393).
Peptide "+" means "with peptide blocking". -
Gene Info — CERKL
Entrez GeneID
375298Protein Accession#
Q49MI3Gene Name
CERKL
Gene Alias
RP26
Gene Description
ceramide kinase-like
Gene Ontology
HyperlinkGene Summary
Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids (Tuson et al., 2004 [PubMed 14681825]).[supplied by OMIM
Other Designations
ceramide kinase-like protein|retinitis pigmentosa 26 (autosomal recessive)
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Disease
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Publication Reference
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Characterization of a ceramide kinase-like protein.
Bornancin F, Mechtcheriakova D, Stora S, Graf C, Wlachos A, Devay P, Urtz N, Baumruker T, Billich A.
Biochimica et Biophysica Acta 2005 Feb; 1687(1-3):31.
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K
Nature Genetics 2003 Dec; 36(1):40.
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Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26).
Tuson M, Marfany G, Gonzalez-Duarte R.
American Journal of Human Genetics 2003 Dec; 74(1):128.
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Characterization of a ceramide kinase-like protein.
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