DOK7 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of extracts from mouse brain cells, using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking".
Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking".
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DOK7.
Immunogen
A synthetic peptide corresponding to N-terminus of human DOK7.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total DOK7 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of extracts from mouse brain cells, using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using DOK7 polyclonal antibody (Cat # PAB17392).
Peptide "+" means "with peptide blocking". -
Gene Info — DOK7
Entrez GeneID
285489Protein Accession#
Q18PE1Gene Name
DOK7
Gene Alias
C4orf25, Dok-7, FLJ33718, FLJ39137, FLJ90556
Gene Description
docking protein 7
Omim ID
610285Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
downstream of tyrosine kinase 7
-
Publication Reference
-
Dok-7 mutations underlie a neuromuscular junction synaptopathy.
Beeson D, Higuchi O, Palace J, Cossins J, Spearman H, Maxwell S, Newsom-Davis J, Burke G, Fawcett P, Motomura M, Muller JS, Lochmuller H, Slater C, Vincent A, Yamanashi Y.
Science 2006 Aug; 313(5795):1975.
Application：WB-Tr, Human, Mouse, C2C12, HEK 293T cells.
-
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y.
Science 2006 Jun; 312(5781):1802.
Application：IF, IHC-Fr, IP, WB, Human, Mouse, C2 myotubes, HEK 293T cells, Mouse muscles.
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K
Nature Genetics 2003 Dec; 36(1):40.
-
Dok-7 mutations underlie a neuromuscular junction synaptopathy.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com