LTB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LTB.
Immunogen
A synthetic peptide corresponding to C-terminus of human LTB.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total LTB protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, using LTB polyclonal antibody (Cat # PAB17378).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using LTB polyclonal antibody (Cat # PAB17378).
Peptide "+" means "with peptide blocking". -
Gene Info — LTB
Entrez GeneID
4050Protein Accession#
Q06643Gene Name
LTB
Gene Alias
TNFC, TNFSF3, p33
Gene Description
lymphotoxin beta (TNF superfamily, member 3)
Omim ID
600978Gene Ontology
HyperlinkGene Summary
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000029185|OTTHUMP00000038214|lymphotoxin-beta|tumor necrosis factor C
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Publication Reference
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A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.
Neville MJ, Campbell RD.
Journal of Immunology 1999 Apr; 162(8):4745.
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Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas.
Warzocha K, Renard N, Charlot C, Bienvenu J, Coiffier B, Salles G.
Biochemical and Biophysical Research Communications 1997 Sep; 238(2):273.
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Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.
Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF.
Cell 1993 Mar; 72(6):847.
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A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.
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