Western blot analysis of extracts from HeLa cells (Lane 1), HepG2 cells (Lane 2) and 293 cells (Lane 3 and lane 4), using MNAT1 polyclonal antibody (Cat # PAB17369). Peptide "+" means "with peptide blocking".
Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM
cyclin G1 interacting protein,cyclin H assembly factor,menage a trois 1 (CAK assembly factor)