MNAT1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MNAT1.
Immunogen
A synthetic peptide corresponding to internal of human MNAT1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total MNAT1 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells (Lane 1), HepG2 cells (Lane 2) and 293 cells (Lane 3 and lane 4), using MNAT1 polyclonal antibody (Cat # PAB17369).
Peptide "+" means "with peptide blocking". -
Gene Info — MNAT1
Entrez GeneID
4331Protein Accession#
P51948Gene Name
MNAT1
Gene Alias
MAT1, RNF66, TFB3
Gene Description
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
Omim ID
602659Gene Ontology
HyperlinkGene Summary
Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM
Other Designations
cyclin G1 interacting protein|cyclin H assembly factor|menage a trois 1 (CAK assembly factor)
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Interactome
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Pathway
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Disease
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Publication Reference
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Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
Tirode F, Busso D, Coin F, Egly JM.
Molecular Cell 1999 Jan; 3(1):87.
Application:KA, WB-Re, Recombinant protein.
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Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.
Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y.
Cancer Research 1995 Dec; 55(24):6058.
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In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
Tassan JP, Jaquenoud M, Fry AM, Frutiger S, Hughes GJ, Nigg EA.
The EMBO Journal 1995 Nov; 14(22):5608.
Application:IF, WB, Human, HeLa cells.
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Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
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