Western blot analysis of extracts from COLO 205 cells (Lane 1 and lane 3) treated with serum (20%, 15 mins), and HUVEC cells (Lane 2) treated with EGF (200 ng/ml, 15 mins), using HOXD12 polyclonal antibody (Cat # PAB17361). Peptide "+" means "with peptide blocking".
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq
Hox-4.7, mouse, homolog of,homeo box D12,homeobox protein Hox-D12