Western blot analysis of extracts from HepG2 cells (Lane 1), HeLa cells (Lane 2) and COLO 205 cells (Lane 3 and lane 4), using AKAP5 polyclonal antibody (Cat # PAB17356). Peptide "+" means "with peptide blocking".
Immunofluorescence analysis of HeLa cells, using AKAP5 polyclonal antibody (Cat # PAB17356). Peptide "+" means "with peptide blocking".
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq
A-kinase anchor protein 5,A-kinase anchor protein, 79kDa,A-kinase anchoring protein 75/79,cAMP-dependent protein kinase regulatory subunit II high affinity binding protein