CDK11B polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells (Lane 1) and HUVEC cells (Lane 2 and lane 3), using CDK11B polyclonal antibody (Cat # PAB17355).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDK11B.
Immunogen
A synthetic peptide corresponding to N-terminus of human CDK11B.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total CDK11B protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells (Lane 1) and HUVEC cells (Lane 2 and lane 3), using CDK11B polyclonal antibody (Cat # PAB17355).
Peptide "+" means "with peptide blocking". -
Gene Info — CDC2L1
Entrez GeneID
984Protein Accession#
P21127Gene Name
CDC2L1
Gene Alias
CDC2L2, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, FLJ59152, PK58, p58, p58CDC2L1, p58CLK-1
Gene Description
cell division cycle 2-like 1 (PITSLRE proteins)
Omim ID
176873Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq
Other Designations
CDC-related protein kinase p58|OTTHUMP00000000760|OTTHUMP00000000767|OTTHUMP00000000768|PITSLRE serine/threonine-protein kinase CDC2L1|PITSLREA|cell division cycle 2-like 2 (PITSLRE proteins)|cell division cycle 2-like protein kinase 1|galactosyltransfera
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Interactome
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Publication Reference
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Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.
Xiang J, Lahti JM, Grenet J, Easton J, Kidd VJ.
The Journal of Biological Chemistry 1994 Jun; 269(22):15786.
Application：IP, WB-Ce, Human, Mouse, BAC1.2F5, CHO, HEK 293, HeLa, K-562, NIH/3T3, PNET cells .
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Structure and expression of the human p58clk-1 protein kinase chromosomal gene.
Eipers PG, Lahti JM, Kidd VJ.
Genomics 1992 Jul; 13(3):613.
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Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.
Bunnell BA, Heath LS, Adams DE, Lahti JM, Kidd VJ.
PNAS 1990 Oct; 87(19):7467.
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Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.
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