ADRA2B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRA2B.
Immunogen
A synthetic peptide corresponding to internal of human ADRA2B.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total ADRA2B protein.
Form
Liquid
Recommend Usage
IImmunofluorescence (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using ADRA2B polyclonal antibody (Cat # PAB17354).
Peptide "+" means "with peptide blocking". -
Gene Info — ADRA2B
Entrez GeneID
151Protein Accession#
P18089Gene Name
ADRA2B
Gene Alias
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR
Gene Description
adrenergic, alpha-2B-, receptor
Omim ID
104260Gene Ontology
HyperlinkGene Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq
Other Designations
ADRA2B adrenergic, alpha-2B-, receptor|G-protein coupled receptor|adrenergic receptor alpha 2B|alpha-2-adrenergic receptor-like 1|alpha-2B-adrenergic receptor
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Publication Reference
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Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.
Small KM, Brown KM, Forbes SL, Liggett SB.
The Journal of Biological Chemistry 2001 Feb; 276(7):4917.
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Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.
Weinshank RL, Zgombick JM, Macchi M, Adham N, Lichtblau H, Branchek TA, Hartig PR.
Molecular Pharmacology 1990 Nov; 38(5):681.
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Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
Lomasney JW, Lorenz W, Allen LF, King K, Regan JW, Yang-Feng TL, Caron MG, Lefkowitz RJ.
PNAS 1990 Jul; 87(13):5094.
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Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.
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