HNRNPC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HNRNPC.
Immunogen
A synthetic peptide corresponding to internal of human HNRNPC.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total HNRNPC protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells (Lane 1 and lane 3) and COLO 205 cells (Lane 2), using HNRNPC polyclonal antibody (Cat # PAB17352).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using HNRNPC polyclonal antibody (Cat # PAB17352).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HUVEC cells, using HNRNPC polyclonal antibody (Cat # PAB17352).
Peptide "+" means "with peptide blocking". -
Gene Info — HNRNPC
Entrez GeneID
3183Protein Accession#
P07910Gene Name
HNRNPC
Gene Alias
C1, C2, HNRNP, HNRPC, MGC104306, MGC105117, MGC117353, MGC131677, SNRPC
Gene Description
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Omim ID
164020Gene Ontology
HyperlinkGene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq
Other Designations
heterogeneous nuclear ribonucleoprotein C|nuclear ribonucleoprotein particle C1 protein|nuclear ribonucleoprotein particle C2 protein
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Interactome
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Publication Reference
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Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
Burd CG, Swanson MS, Gorlach M, Dreyfuss G.
PNAS 1989 Dec; 86(24):9788.
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Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles.
Merrill BM, Barnett SF, LeStourgeon WM, Williams KR.
Nucleic Acids Research 1989 Nov; 17(21):8441.
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Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
Swanson MS, Nakagawa TY, LeVan K, Dreyfuss G.
Molecular and Cellular Biology 1987 May; 7(5):1731.
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Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
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