SIX6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HUVEC cells (Lane 1 and lane 3) and COLO 205 cells (Lane 2), using SIX6 polyclonal antibody (Cat # PAB17349).
Peptide "+" means "with peptide blocking".
Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using SIX6 polyclonal antibody (Cat # PAB17349).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIX6.
Immunogen
A synthetic peptide corresponding to internal of human SIX6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total SIX6 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HUVEC cells (Lane 1 and lane 3) and COLO 205 cells (Lane 2), using SIX6 polyclonal antibody (Cat # PAB17349).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using SIX6 polyclonal antibody (Cat # PAB17349).
Peptide "+" means "with peptide blocking". -
Gene Info — SIX6
Entrez GeneID
4990Protein Accession#
O95475Gene Name
SIX6
Gene Alias
MCOPCT2, OPTX2, Six9
Gene Description
SIX homeobox 6
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq
Other Designations
OTTHUMP00000070922|optic homeobox 2|sine oculis homeobox homolog 6
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Interactome
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Disease
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Publication Reference
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Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia.
Gallardo ME, Rodriguez De Cordoba S, Schneider AS, Dwyer MA, Ayuso C, Bovolenta P.
American Journal of Medical Genetics. Part A 2004 Aug; 129A(1):92.
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Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies.
Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S.
Genomics 1999 Oct; 61(1):82.
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Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development.
Lopez-Rios J, Gallardo ME, Rodriguez de Cordoba S, Bovolenta P.
Mechanisms of Development 1999 May; 83(1-2):155.
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Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia.
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