TADA2A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells (Lane 1 and lane 3) and COLO 205 cells (Lane 2), using TADA2A polyclonal antibody (Cat # PAB17345).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TADA2A.
Immunogen
A synthetic peptide corresponding to internal of human TADA2A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total TADA2A protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells (Lane 1 and lane 3) and COLO 205 cells (Lane 2), using TADA2A polyclonal antibody (Cat # PAB17345).
Peptide "+" means "with peptide blocking". -
Gene Info — TADA2L
Entrez GeneID
6871Protein Accession#
O75478Gene Name
TADA2L
Gene Alias
ADA2, ADA2A, FLJ12705, KL04P, hADA2
Gene Description
transcriptional adaptor 2 (ADA2 homolog, yeast)-like
Omim ID
602276Gene Ontology
HyperlinkGene Summary
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
ADA2-like|OTTHUMP00000164063|transcriptional adaptor 2 (ADA2, yeast, homolog)-like|transcriptional adaptor 2 alpha|transcriptional adaptor 2-like
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Interactome
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Disease
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Publication Reference
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Histone-like TAFs within the PCAF histone acetylase complex.
Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y.
Cell 1998 Jul; 94(1):35.
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Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor.
Henriksson A, Almlof T, Ford J, McEwan IJ, Gustafsson JA, Wright AP.
Molecular and Cellular Biology 1997 Jun; 17(6):3065.
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Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL.
Molecular and Cellular Biology 1996 Feb; 16(2):593.
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Histone-like TAFs within the PCAF histone acetylase complex.
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