GSC2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells (Lane 1), HepG2 cells (Lane 2) and COLO 205 cells (Lane 3 and 4), using GSC2 polyclonal antibody (Cat # PAB17336).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GSC2.
Immunogen
A synthetic peptide corresponding to internal of human GSC2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total GSC2 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells (Lane 1), HepG2 cells (Lane 2) and COLO 205 cells (Lane 3 and 4), using GSC2 polyclonal antibody (Cat # PAB17336).
Peptide "+" means "with peptide blocking". -
Gene Info — GSC2
Entrez GeneID
2928Protein Accession#
O15499Gene Name
GSC2
Gene Alias
GSCL
Gene Description
goosecoid homeobox 2
Omim ID
601845Gene Ontology
HyperlinkGene Summary
Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. [provided by RefSeq
Other Designations
goosecoid-like
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Interactome
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Publication Reference
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Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11.
Funke B, Saint-Jore B, Puech A, Sirotkin H, Edelmann L, Carlson C, Raft S, Pandita RK, Kucherlapati R, Skoultchi A, Morrow BE.
Genomics 1997 Dec; 46(3):364.
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The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development.
Gottlieb S, Emanuel BS, Driscoll DA, Sellinger B, Wang Z, Roe B, Budarf ML.
American Journal of Human Genetics 1997 May; 60(5):1194.
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Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11.
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