ERCC4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERCC4.
Immunogen
A synthetic peptide corresponding to internal of human ERCC4.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total ERCC4 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells, using ERCC4 polyclonal antibody (Cat # PAB17332).
Peptide "+" means "with peptide blocking". -
Gene Info — ERCC4
Entrez GeneID
2072Protein Accession#
Q92889Gene Name
ERCC4
Gene Alias
RAD1, XPF
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6)
Other Designations
excision-repair, complementing defective, in Chinese hamster|xeroderma pigmentosum, complementation group F
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Interactome
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Pathway
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Disease
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Publication Reference
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A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.
Cleaver JE, Thompson LH, Richardson AS, States JC.
Human Mutation 1999 Jan; 14(1):9.
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ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs.
Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris CN, Thompson LH.
Molecular and Cellular Biology 1996 Nov; 16(11):6553.
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Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.
Sijbers AM, de Laat WL, Ariza RR, Biggerstaff M, Wei YF, Moggs JG, Carter KC, Shell BK, Evans E, de Jong MC, Rademakers S, de Rooij J, Jaspers NG, Hoeijmakers JH, Wood RD.
Cell 1996 Sep; 86(5):811.
Application:WB-Ce, WB-Re, Hamster, Human, CHO9 cells, HeLa cells, Recombinant proteins.
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A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.
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