NRG1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NRG1.
Immunogen
A synthetic peptide corresponding to human NRG1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total NRG1 protein.
Form
Liquid
Recommend Usage
Western Blot (1:300-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from SK-OV-3 cells, using NRG1 polyclonal antibody (Cat # PAB17327).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using NRG1 polyclonal antibody (Cat # PAB17327).
Peptide "+" means "with peptide blocking". -
Gene Info — NRG1
Entrez GeneID
3084Protein Accession#
Q15491Gene Name
NRG1
Gene Alias
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF
Gene Description
neuregulin 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq
Other Designations
glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 isoform HRG-gamma|sensory and motor neuron derived factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential signaling by an anti-p185(HER2) antibody and heregulin.
Le XF, Vadlamudi R, McWatters A, Bae DS, Mills GB, Kumar R, Bast RC Jr.
Cancer Research 2000 Jul; 60(13):3522.
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Heregulin activation of extracellular acidification in mammary carcinoma cells is associated with expression of HER2 and HER3.
Chan SD, Antoniucci DM, Fok KS, Alajoki ML, Harkins RN, Thompson SA, Wada HG.
The Journal of Biological Chemistry 1995 Sep; 270(38):22608.
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Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85.
Gamett DC, Greene T, Wagreich AR, Kim HH, Koland JG, Cerione RA.
The Journal of Biological Chemistry 1995 Aug; 270(32):19022.
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Differential signaling by an anti-p185(HER2) antibody and heregulin.
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