CAD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAD.
Immunogen
A synthetic peptide corresponding to internal of human CAD.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total CAD protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using CAD polyclonal antibody (Cat # PAB17323).
Peptide "+" means "with peptide blocking". -
Gene Info — CAD
Entrez GeneID
790Protein Accession#
P27708Gene Name
CAD
Gene Alias
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Gene Description
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Omim ID
114010Gene Ontology
HyperlinkGene Summary
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq
Other Designations
CAD trifunctional protein|carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase|multifunctional protein CAD
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Interactome
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Pathway
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Disease
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Publication Reference
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
Cell 2006 Nov; 127(3):635.
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Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M.
Biochemical and Biophysical Research Communications 1996 Feb; 219(1):249.
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Organization and nucleotide sequence of the 3' end of the human CAD gene.
Davidson JN, Rao GN, Niswander L, Andreano C, Tamer C, Chen KC.
DNA and Cell Biology 1990 Nov; 9(9):667.
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
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