RBBP8 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RBBP8.
Immunogen
A synthetic peptide corresponding to internal of human RBBP8.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total RBBP8 protein
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using RBBP8 polyclonal antibody (Cat # PAB17317).
Peptide "+" means "with peptide blocking". -
Gene Info — RBBP8
Entrez GeneID
5932Protein Accession#
Q99708Gene Name
RBBP8
Gene Alias
CTIP, RIM
Gene Description
retinoblastoma binding protein 8
Omim ID
604124Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq
Other Designations
CTBP-interacting protein|retinoblastoma-binding protein 8|retinoblastoma-interacting myosin-like
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Interactome
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Disease
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Publication Reference
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Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma.
Kawaguchi A, Iwadate Y, Komohara Y, Sano M, Kajiwara K, Yajima N, Tsuchiya N, Homma J, Aoki H, Kobayashi T, Sakai Y, Hondoh H, Fujii Y, Kakuma T, Yamanaka R.
Clinical Cancer Research 2012 Oct; 18(20):5672.
Application:IHC-P, Human, Human primary central nervous system lymphoma.
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Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.
Yu X, Baer R.
The Journal of Biological Chemistry 2000 Jun; 275(24):18541.
Application:WB, Human, HBL-100, HCT-116, T24 cells.
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Molecular cloning and characterization of a novel retinoblastoma-binding protein.
Fusco C, Reymond A, Zervos AS.
Genomics 1998 Aug; 51(3):351.
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Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif.
Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G.
The Journal of Biological Chemistry 1998 Apr; 273(15):8549.
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Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma.
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