HNRNPC polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HUVEC cells, treated with EGF (200 ng/ml, 5 mins), using HNRNPC polyclonal antibody (Cat # PAB17311).
Peptide "+" means "with peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using HNRNPC polyclonal antibody (Cat # PAB17311).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HNRNPC.
Immunogen
A synthetic peptide corresponding to residues surrounding serine 260 of human HNRNPC.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total HNRNPC protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HUVEC cells, treated with EGF (200 ng/ml, 5 mins), using HNRNPC polyclonal antibody (Cat # PAB17311).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using HNRNPC polyclonal antibody (Cat # PAB17311).
Peptide "+" means "with peptide blocking". -
Gene Info — HNRNPC
Entrez GeneID
3183Protein Accession#
P07910Gene Name
HNRNPC
Gene Alias
C1, C2, HNRNP, HNRPC, MGC104306, MGC105117, MGC117353, MGC131677, SNRPC
Gene Description
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Omim ID
164020Gene Ontology
HyperlinkGene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq
Other Designations
heterogeneous nuclear ribonucleoprotein C|nuclear ribonucleoprotein particle C1 protein|nuclear ribonucleoprotein particle C2 protein
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Interactome
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Publication Reference
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SUMO modification of heterogeneous nuclear ribonucleoproteins.
Vassileva MT, Matunis MJ.
Molecular and Cellular Biology 2004 May; 24(9):3623.
Application：IP, Human, HeLa cells.
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The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.
Huang M, Rech JE, Northington SJ, Flicker PF, Mayeda A, Krainer AR, LeStourgeon WM.
Molecular and Cellular Biology 1994 Jan; 14(1):518.
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Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
Burd CG, Swanson MS, Gorlach M, Dreyfuss G.
PNAS 1989 Dec; 86(24):9788.
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SUMO modification of heterogeneous nuclear ribonucleoproteins.
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