ICAM3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ICAM3.
Immunogen
A synthetic peptide corresponding to residues surrounding serine 518 of human ICAM3.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total ICAM-3 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, treated with TNF-a (20 ng/ml, 5 mins), using ICAM3 polyclonal antibody (Cat # PAB17305).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of A-549 cells, using ICAM3 polyclonal antibody (Cat # PAB17305).
Peptide "+" means "with peptide blocking". -
Gene Info — ICAM3
Entrez GeneID
3385Protein Accession#
P32942Gene Name
ICAM3
Gene Alias
CD50, CDW50, ICAM-R
Gene Description
intercellular adhesion molecule 3
Omim ID
146631Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq
Other Designations
intercellular adhesion molecule-3
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Interactome
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Pathway
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Disease
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Publication Reference
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Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD.
Journal of Proteome Research 2005 Nov; 4(6):2070.
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Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.
de Fougerolles AR, Klickstein LB, Springer TA.
The Journal of Experimental Medicine 1993 Apr; 177(4):1187.
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Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.
Fawcett J, Holness CL, Needham LA, Turley H, Gatter KC, Mason DY, Simmons DL.
Nature 1992 Dec; 360(6403):481.
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Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
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