HIST1H2BB polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, treated with UV (15 mins), using HIST1H2BB polyclonal antibody (Cat # PAB17301).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HIST1H2BB.
Immunogen
A synthetic peptide corresponding to residues surrounding serine 14 of human HIST1H2BB.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total HIST1H2BB protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, treated with UV (15 mins), using HIST1H2BB polyclonal antibody (Cat # PAB17301).
Peptide "+" means "with peptide blocking". -
Gene Info — HIST1H2BB
Entrez GeneID
3018Protein Accession#
P33778Gene Name
HIST1H2BB
Gene Alias
H2B.1, H2B/f, H2BFF, MGC119804
Gene Description
histone cluster 1, H2bb
Omim ID
602803Gene Ontology
HyperlinkGene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq
Other Designations
H2B histone family, member F|OTTHUMP00000016138|histone 1, H2bb
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Interactome
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Pathway
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Publication Reference
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The human and mouse replication-dependent histone genes.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ.
Genomics 2002 Nov; 80(5):487.
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Global regulation of post-translational modifications on core histones.
Galasinski SC, Louie DF, Gloor KK, Resing KA, Ahn NG.
The Journal of Biological Chemistry 2001 Nov; 277(4):2579.
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Isolation and characterization of two human H1 histone genes within clusters of core histone genes.
Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D.
Genomics 1991 Aug; 10(4):940.
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The human and mouse replication-dependent histone genes.
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