RYR2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RYR2.
Immunogen
A synthetic peptide corresponding to internal of human RYR2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total RYR2 protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using RYR2 polyclonal antibody (Cat # PAB17291).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of NIH/3T3 cells, using RYR2 polyclonal antibody (Cat # PAB17291).
Peptide "+" means "with peptide blocking". -
Gene Info — RYR2
Entrez GeneID
6262Protein Accession#
Q92736Gene Name
RYR2
Gene Alias
ARVC2, ARVD2, VTSIP
Gene Description
ryanodine receptor 2 (cardiac)
Gene Ontology
HyperlinkGene Summary
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq
Other Designations
cardiac muscle ryanodine receptor|cardiac muscle ryanodine receptor-calcium release channel
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).
Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli GA, Rampazzo A.
Human Molecular Genetics 2001 Feb; 10(3):189.
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The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis.
Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA.
The Biochemical Journal 1996 Sep; 318 ( Pt 2)(Pt 2):477.
Application:C-ELISA, WB-Ti, Human, Rabbit, Cardiac muscles.
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Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).
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