RAD9A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RAD9A.
Immunogen
A synthetic peptide corresponding to internal of human RAD9A.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total RAD9A protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RAD9A polyclonal antibody (Cat # PAB17290).
Peptide "+" means "with peptide blocking". -
Gene Info — RAD9A
Entrez GeneID
5883Protein Accession#
Q96C41Gene Name
RAD9A
Gene Alias
RAD9
Gene Description
RAD9 homolog A (S. pombe)
Omim ID
603761Gene Ontology
HyperlinkGene Summary
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq
Other Designations
RAD9 homolog|cell cycle checkpoint control protein
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Interactome
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Disease
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Publication Reference
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Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
Roos-Mattjus P, Hopkins KM, Oestreich AJ, Vroman BT, Johnson KL, Naylor S, Lieberman HB, Karnitz LM.
The Journal of Biological Chemistry 2003 Jul; 278(27):24428.
Application:IP-WB, Mouse, Es cells.
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c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Yoshida K, Komatsu K, Wang HG, Kufe D.
Molecular and Cellular Biology 2002 May; 22(10):3292.
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Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.
Hang H, Rauth SJ, Hopkins KM, Lieberman HB.
Nucleic Acids Research 2000 Nov; 28(21):4340.
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Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
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