GRLF1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRLF1.
Immunogen
A synthetic peptide corresponding to internal of human GRLF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total GRFL1 protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using GRLF1 polyclonal antibody (Cat # PAB17285).
Peptide "+" means "with peptide blocking". -
Gene Info — GRLF1
Entrez GeneID
2909Protein Accession#
Q9NRY4Gene Name
GRLF1
Gene Alias
GRF-1, KIAA1722, MGC10745, P190-A, P190A, p190RhoGAP
Gene Description
glucocorticoid receptor DNA binding factor 1
Omim ID
605277Gene Ontology
HyperlinkGene Summary
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival.
Li L, Li YM, Zhou P, Wang XS, Wang GY, Zhao XH, Cui BB, Ren YL, Dong XS, Chen ZQ.
American Journal of Translational Research 2016 Oct; 8(10):4405.
Application:WB-Ti, IHC-P, Human, Human colon cancer.
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Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Daisuke Nakajima, Noriko Okazaki, Hisashi Yamakawa, Reiko Kikuno, Osamu Ohara, Takahiro Nagase.
DNA Research 2002 Jun; 9(3):99.
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Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O.
DNA Research 2000 Dec; 7(6):347.
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p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.
Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H.
Gene 2000 Oct; 257(1):23.
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Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival.
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