RBBP8 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RBBP8 polyclonal antibody (Cat # PAB17283).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RBBP8.
Immunogen
A synthetic peptide corresponding to internal of human RBBP8.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total RBBP8 protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RBBP8 polyclonal antibody (Cat # PAB17283).
Peptide "+" means "with peptide blocking". -
Gene Info — RBBP8
Entrez GeneID
5932Protein Accession#
Q99708Gene Name
RBBP8
Gene Alias
CTIP, RIM
Gene Description
retinoblastoma binding protein 8
Omim ID
604124Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq
Other Designations
CTBP-interacting protein|retinoblastoma-binding protein 8|retinoblastoma-interacting myosin-like
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Interactome
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Disease
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Publication Reference
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RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.
Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knochel W, Borggrefe T.
Molecular and Cellular Biology 2005 Dec; 25(23):10379.
Application：WB-Ce, Human, Jurkat T cells.
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Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency.
Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH.
Molecular and Cellular Biology 2005 May; 25(9):3535.
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Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage.
Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH.
The Journal of Biological Chemistry 1999 Apr; 274(16):11334.
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RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.
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