PLCB3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PLCB3.
Immunogen
A synthetic peptide corresponding to residues surrounding serine 1105 of human PLCB3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total PLCB3 protein.
Form
Liquid
Recommend Usage
Westen Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells treated with PMA (125 ng/ml, 30 min), using PLCB3 polyclonal antibody (Cat # PAB17281).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using PLCB3 polyclonal antibody (Cat # PAB17281).
Peptide "+" means "with peptide blocking". -
Gene Info — PLCB3
Entrez GeneID
5331Protein Accession#
Q01970Gene Name
PLCB3
Gene Alias
FLJ37084
Gene Description
phospholipase C, beta 3 (phosphatidylinositol-specific)
Omim ID
600230Gene Ontology
HyperlinkGene Summary
PLCB3 plays an important role in initiating receptor-mediated signal transduction. Activation of PLC takes place in many cells as a response to stimulation by hormones, growth factors, neurotransmitters, and other ligands (Lagercrantz et al., 1995 [PubMed 7607669]).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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WenTong HuoXue Cream Can Inhibit the Reduction of the Pain-Related Molecule PLC-β3 in the Dorsal Root Ganglion of a Rat Model of Diabetic Peripheral Neuropathy.
Feng C, Xu L, Guo S, Chen Q, Shen Y, Zang D, Ma L.
Evidence-Based Complementary and Alternative Medicine : ECAM. 2018 Feb; 2018:3416936.
Application:WB-Ti, Rat, Rat dorsal root ganglion.
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Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C.
Frecker H, Munk S, Wang H, Whiteside C.
American Journal of Physiology. Renal Physiology 2005 Jul; 289(5):F1078.
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Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes.
Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S.
The Journal of Biological Chemistry 2004 Nov; 279(45):47159.
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WenTong HuoXue Cream Can Inhibit the Reduction of the Pain-Related Molecule PLC-β3 in the Dorsal Root Ganglion of a Rat Model of Diabetic Peripheral Neuropathy.
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