ATXN3 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATXN3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 29-59 at N-terminus of human ATXN3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with ATXN3 polyclonal antibody (Cat # PAB1728) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — ATXN3
Entrez GeneID
4287Protein Accession#
NP_004984;P54252Gene Name
ATXN3
Gene Alias
AT3, ATX3, JOS, MJD, MJD1, SCA3
Gene Description
ataxin 3
Gene Ontology
HyperlinkGene Summary
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)|Machado-Joseph disease protein 1|josephin|olivopontocerebellar ataxia 3|spinocerebellar ataxia type 3 protein
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Interactome
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Disease
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Publication Reference
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Neuroprotective effects of creatine in the CMVMJD135 mouse model of spinocerebellar ataxia type 3.
Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P.
Movement Disorders 2018 May; 33(5):815.
Application:WB, Mouse, Brain.
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Structural and functional analysis of ataxin-2 and ataxin-3.
Albrecht M, Golatta M, Wullner U, Lengauer T.
European Journal of Biochemistry 2004 Aug; 271(15):3155.
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Molecular architecture of CAG repeats in human disease related transcripts.
Michlewski G, Krzyzosiak WJ.
Journal of Molecular Biology 2004 Jul; 340(4):665.
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Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA.
Li Y, Yokota T, Matsumura R, Taira K, Mizusawa H.
Annals of Neurology 2004 Jul; 56(1):124.
Application:WB-Tr, Human, HEK 293T cells.
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Neuroprotective effects of creatine in the CMVMJD135 mouse model of spinocerebellar ataxia type 3.
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