SRF polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
SRF polyclonal antibody (Cat # PAB17277) staining (1 ug/mL) of TGF-bl-treated primary cultured human lung fibroblast lysate. Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Data kindly provided by Nickolai Dulin, Dept Medicine/Pulmonary, Chicago, USA.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SRF.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human SRF.
Sequence
C-QASPSRDSSTDLTQ
Host
Goat
Theoretical MW (kDa)
51.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SRF polyclonal antibody (Cat # PAB17277) staining (1 ug/mL) of TGF-bl-treated primary cultured human lung fibroblast lysate. Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Data kindly provided by Nickolai Dulin, Dept Medicine/Pulmonary, Chicago, USA.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SRF
Entrez GeneID
6722Protein Accession#
NP_003122.1Gene Name
SRF
Gene Alias
MCM1
Gene Description
serum response factor (c-fos serum response element-binding transcription factor)
Omim ID
600589Gene Ontology
HyperlinkGene Summary
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq
Other Designations
OTTHUMP00000039820
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Interactome
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Pathway
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Disease
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Publication Reference
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Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas.
Raimundo N, Vanharanta S, Aaltonen LA, Hovatta I, Suomalainen A.
Oncogene 2009 Jan; 28(9):1261.
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Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas.
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