IL2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against IL2.
Immunogen
Human IL2.
Host
Rabbit
Reactivity
Human
Form
Lyophilized
Recommend Usage
ELISA (1-2 ug/mL)
Western blot (2-10 ug/mL)
Immunohistochemistry (2-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
The lyophilized antibody is stable for at least 1 year from date of receipt at -20°C.
After reconstitution with 0.01 M PBS, pH 7.4 or other diluents, this antibody can be stored in working aliquots at 2°C- 8°C for one month, or at -20°C for six months without detectable loss of activity.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL2
Entrez GeneID
3558Protein Accession#
P60568Gene Name
IL2
Gene Alias
IL-2, TCGF, lymphokine
Gene Description
interleukin 2
Omim ID
147680Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq
Other Designations
T cell growth factor|aldesleukin|interleukin-2|involved in regulation of T-cell clonal expansion
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Interactome
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Pathway
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Disease
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Publication Reference
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Vaccination with live Leishmania major and CpG DNA promotes interleukin-2 production by dermal dendritic cells and NK cell activation.
Laabs EM, Wu W, Mendez S.
Clinical and Vaccine Immunology : CVI 2009 Sep; 16(11):1601.
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A glucocorticoid amplifies IL-2-induced selective expansion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation.
Xie Y, Wu M, Song R, Ma J, Shi Y, Qin W, Jin Y.
Acta Biochimica et Biophysica Sinica 2009 Sep; 41(9):781.
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ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.
Li X, Chaudry IH, Choudhry MA.
Journal of Immunology 2009 Aug; 183(6):3955.
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Vaccination with live Leishmania major and CpG DNA promotes interleukin-2 production by dermal dendritic cells and NK cell activation.
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