HDAC6 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The HDAC6 polyclonal antibody (Cat # PAB1714) is used in Western blot to detect HDAC6 in mouse kidney tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with HDAC6 polyclonal antibody (Cat # PAB1714) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human HDAC6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The HDAC6 polyclonal antibody (Cat # PAB1714) is used in Western blot to detect HDAC6 in mouse kidney tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with HDAC6 polyclonal antibody (Cat # PAB1714) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — HDAC6
Entrez GeneID
10013Protein Accession#
HDA6_HUMANGene Name
HDAC6
Gene Alias
FLJ16239, HD6, JM21
Gene Description
histone deacetylase 6
Omim ID
300272Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq
Other Designations
OTTHUMP00000032398
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Interactome
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Disease
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Publication Reference
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Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Grozinger CM, Hassig CA, Schreiber SL.
PNAS 1999 Apr; 96(9):4868.
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Transcriptional control. Sinful repression.
Wolffe AP.
Nature 1997 May; 387(6628):16.
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Three proteins define a class of human histone deacetylases related to yeast Hda1p.
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