SCG2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against SCG2.
Immunogen
N-terminus sequence (amino acids 1-19) of human and rat SCG2/Scg2 coupled to ovalbumin.
Host
Rabbit
Reactivity
Human, Rat
Specificity
This antibody reacts speci cally with rat and human secretogranin II.
Form
Liquid
Recommend Usage
Western Blot (1:2500-1:10000)
Immunoprecipitation (1:100-1:500)
Immunohistochemistry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — SCG2
Entrez GeneID
7857Gene Name
SCG2
Gene Alias
CHGC, SN, SgII
Gene Description
secretogranin II (chromogranin C)
Omim ID
118930Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq
Other Designations
Chromogranin C (secretogranin II)|EM66|secretogranin II|secretoneurin
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Gene Info — Scg2
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Interactome
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Publication Reference
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Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
Berard AR, Severini A, Coombs KM.
Journal of Virology 2015 Dec; 89(23):11954.
Application：WB, Human, HEK 293 cells.
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Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection.
Berard AR, Cortens JP, Krokhin O, Wilkins JA, Severini A, Coombs KM.
PLoS One 2012 Dec; 7(12):e51939.
Application：WB-Ce, Human, HEK 293.
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Prolactin granulogenesis is associated with increased secretogranin expression and aggregation in the Golgi apparatus of GH4C1 cells.
Thompson ME, Zimmer WE, Haynes AL, Valentine DL, Forss-Petter S, Scammell JG.
Endocrinology 1992 Jul; 131(1):318.
Application：IF, WB-Re, Rat, GH4C1 cells, Purified proteins.
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Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
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