EPS15 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EPS15.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human EPS15.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of EPS15 polyclonal antibody (Cat # PAB1705) in HL-60 cell line lysate (35 ug/lane). EPS15 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — EPS15
Entrez GeneID
2060Protein Accession#
EP15_HUMANGene Name
EPS15
Gene Alias
AF-1P, AF1P, MLLT5
Gene Description
epidermal growth factor receptor pathway substrate 15
Omim ID
600051Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
ALL1 fused gene from chromosome 1|OTTHUMP00000009896
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular mechanism of NPF recognition by EH domains.
de Beer T, Hoofnagle AN, Enmon JL, Bowers RC, Yamabhai M, Kay BK, Overduin M.
Nature Structural Biology 2000 Nov; 7(11):1018.
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Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
Enmon JL, de Beer T, Overduin M.
Biochemistry 2000 Apr; 39(15):4309.
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Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
de Beer T, Carter RE, Lobel-Rice KE, Sorkin A, Overduin M.
Science 1998 Aug; 281(5381):1357.
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Molecular mechanism of NPF recognition by EH domains.
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