DPM2 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DPM2.
Immunogen
A synthetic peptide corresponding to human DPM2.
Sequence
C-SYVMLKTKRVTKKAQ
Host
Goat
Theoretical MW (kDa)
9.31
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — DPM2
Entrez GeneID
8818Protein Accession#
NP_003854.1Gene Name
DPM2
Gene Alias
FLJ80013, MGC111193, MGC21559
Gene Description
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Omim ID
603564Gene Ontology
HyperlinkGene Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq
Other Designations
OTTHUMP00000022224|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol phosphate-mannose synthase 2
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Interactome
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Pathway
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Publication Reference
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Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T.
The EMBO Journal 2000 Aug; 19(16):4402.
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Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
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