UBQLN2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The UBQLN2 polyclonal antibody (Cat # PAB1699) is used in Western blot to detect UBQLN2 in HeLa cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UBQLN2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human UBQLN2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The UBQLN2 polyclonal antibody (Cat # PAB1699) is used in Western blot to detect UBQLN2 in HeLa cell lysate. -
Gene Info — UBQLN2
Entrez GeneID
29978Protein Accession#
Q9UHD9Gene Name
UBQLN2
Gene Alias
CHAP1, CHAP1/DSK2, Dsk2, HRIHFB2157, LIC-2, N4BP4, PLIC-2, PLIC2, RIHFB2157
Gene Description
ubiquilin 2
Omim ID
300264Gene Ontology
HyperlinkGene Summary
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq
Other Designations
Nedd4 binding protein 4|bA431N15.1 (ubiquilin 2)
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Interactome
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Publication Reference
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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM.
Biochemistry 2002 Feb; 41(6):1767.
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The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.
Molecular Cell 2000 Aug; 6(2):409.
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Selection system for genes encoding nuclear-targeted proteins.
Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M.
Nature Biotechnology 1998 Dec; 16(13):1338.
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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
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