GRIN1 (phospho S897) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of GRIN1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S897 of human GRIN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of GRIN1 only when phosphorylated at serine 897.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using GRIN1 (phospho Ser897) polyclonal antibody (Cat # PAB16978). -
Gene Info — GRIN1
Entrez GeneID
2902Protein Accession#
Q05586Gene Name
GRIN1
Gene Alias
NMDA1, NMDAR1, NR1
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Omim ID
138249Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor channel, subunit zeta-1|NMDA receptor 1|OTTHUMP00000022678|glutamate [NMDA] receptor subunit zeta 1
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Interactome
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Publication Reference
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Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development.
Liu XB, Murray KD, Jones EG.
Journal of Neuroscience 2004 Oct; 24(40):8885.
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Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
Emamian ES, Karayiorgou M, Gogos JA.
The Journal of Neuroscience 2004 Feb; 24(7):1561.
Application:WB-Ti, Human, Brain.
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An NMDA receptor signaling complex with protein phosphatase 2A.
Chan SF, Sucher NJ.
Journal of Neuroscience 2001 Oct; 21(20):7985.
Application:WB-Tr, Human, HEK 293 cells.
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Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development.
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