IGF1R (phospho Y980) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of IGF1R.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y980 of human IGF1R.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 980.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using IGF1R (phospho Tyr980) polyclonal antibody (Cat # PAB16974). -
Gene Info — IGF1R
Entrez GeneID
3480Protein Accession#
P08069Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
- Barrett Esophagus
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Publication Reference
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Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects.
Scheidegger KJ, Cenni B, Picard D, Delafontaine P.
The Journal of Biological Chemistry 2000 Dec; 275(49):38921.
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The contradictions of the insulin-like growth factor 1 receptor.
Baserga R.
Oncogene 2000 Nov; 19(49):5574.
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Structure and function of the type 1 insulin-like growth factor receptor.
Adams TE, Epa VC, Garrett TP, Ward CW.
Cellular and Molecular Life Sciences 2000 Jul; 57(7):1050.
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Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects.
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