STK11 (phospho S428) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from CV-1 cells treated with forsklin.
Lane 1 : Using STK11 (phospho Ser428) polyclonal antibody (Cat # PAB16957).
Lane 2 : Using the same antibody preincubated with synthesized peptide.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STK11 (phospho Ser428) polyclonal antibody (Cat # PAB16957).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of STK11.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S428 of human STK11.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of STK11 only when phosphorylated at serine 428.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from CV-1 cells treated with forsklin.
Lane 1 : Using STK11 (phospho Ser428) polyclonal antibody (Cat # PAB16957).
Lane 2 : Using the same antibody preincubated with synthesized peptide.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STK11 (phospho Ser428) polyclonal antibody (Cat # PAB16957).Enzyme-linked Immunoabsorbent Assay
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Gene Info — STK11
Entrez GeneID
6794Protein Accession#
Q15831Gene Name
STK11
Gene Alias
LKB1, PJS
Gene Description
serine/threonine kinase 11
Gene Ontology
HyperlinkGene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
polarization-related protein LKB1|serine/threonine protein kinase 11
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Interactome
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Pathway
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Disease
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Publication Reference
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.
PNAS 2004 Feb; 101(10):3329.
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D.
Current Biology 2003 Nov; 13(22):2004.
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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J.
Molecular Cell 2001 Jun; 7(6):1307.
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
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