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Last updated: 2016/10/16
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PRKAB1 (phospho S182) polyclonal antibody

  • Catalog # : PAB16948
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of PRKAB1.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S182 of human PRKAB1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody detects endogenous levels of PRKAB1 only when phosphorylated at serine 182.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunohistochemistry (1:50-1:100)
    ELISA (1:4000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extracts from Jurkat cells.
    Lane 1 : Using PRKAB1 (phospho S182) polyclonal antibody (Cat # PAB16948).
    Lane 2 : Using the same antibody preincubated with synthesized peptide.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PRKAB1 (phospho S182) polyclonal antibody (Cat # PAB16948).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5564
  • Gene Name:
  • PRKAB1
  • Gene Alias:
  • AMPK,HAMPKb,MGC17785
  • Gene Description:
  • protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Gene Summary:
  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq
  • Other Designations:
  • 5'-AMP-activated protein kinase beta-1 subunit,AMP-activated protein kinase beta 1 non-catalytic subunit,AMP-activated protein kinase beta subunit,AMPK beta -1 chain,AMPK beta 1,protein kinase, AMP-activated, noncatalytic, beta-1
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