STUB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The STUB1 polyclonal antibody (Cat # PAB1693) is used in Western blot to detect STUB1 in HepG2 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STUB1 polyclonal antibody (Cat # PAB1693) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STUB1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 160-190 at C-terminus of human STUB1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The STUB1 polyclonal antibody (Cat # PAB1693) is used in Western blot to detect STUB1 in HepG2 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STUB1 polyclonal antibody (Cat # PAB1693) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — STUB1
Entrez GeneID
10273Protein Accession#
Q969U2Gene Name
STUB1
Gene Alias
CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1
Gene Description
STIP1 homology and U-box containing protein 1
Omim ID
607207Gene Ontology
HyperlinkGene Summary
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM
Other Designations
heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7
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Interactome
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Pathway
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Publication Reference
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Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
Peng HM, Morishima Y, Jenkins GJ, Dunbar AY, Lau M, Patterson C, Pratt WB, Osawa Y.
The Journal of Biological Chemistry 2004 Dec; 279(51):52970.
Application：WB-Tr, Human, Monkey, COS-7, HEK 293T cells.
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.
PNAS 2004 Aug; 101(33):12130.
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The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Alberti S, Bohse K, Arndt V, Schmitz A, Hohfeld J.
Molecular Biology of the Cell 2004 Jun; 15(9):4003.
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Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
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