SQSTM1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SQSTM1 in human spleen tissue lysate with SQSTM1 polyclonal antibody (Cat # PAB16850) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry
Immunohistochemical staining of rat spleen tissue with 5 ug/mL SQSTM1 polyclonal antibody (Cat # PAB16850).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SQSTM1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human SQSTM1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SQSTM1 in human spleen tissue lysate with SQSTM1 polyclonal antibody (Cat # PAB16850) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemical staining of rat spleen tissue with 5 ug/mL SQSTM1 polyclonal antibody (Cat # PAB16850).Enzyme-linked Immunoabsorbent Assay
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Gene Info — SQSTM1
Entrez GeneID
8878Protein Accession#
Q13501Gene Name
SQSTM1
Gene Alias
A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Gene Description
sequestosome 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq
Other Designations
EBI3-associated protein p60|Paget disease of bone 3|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|ubiquitin-binding protein p62
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Interactome
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Disease
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Publication Reference
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Isoform-dependent lysosomal degradation and internalization of Apolipoprotein E requires autophagy proteins.
Gianna M. Fote, Nicolette R. Geller, Nikolaos E. Efstathiou, Nathan Hendricks, Demetrios G. Vavvas, Jack C. Reidling, Leslie M. Thompson, Joan S. Steffan.
Journal of Cell Science 2022 Jan; 135(2):jcs258687.
Application：WB-Ce, Human, HEK293 cells.
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Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.
Park S, Han S, Choi I, Kim B, Park SP, Joe EH, Suh YH.
PLoS One 2016 Sep; 11(9):e0163029.
Application：IP-WB, WB-Tr, Human, Rat, HEK 293T cells, Rat brain.
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A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates.
Yefimova MG, Messaddeq N, Harnois T, Meunier AC, Clarhaut J, Noblanc A, Weickert JL, Cantereau A, Philippe M, Bourmeyster N, Benzakour O.
Autophagy 2013 May; 9(5):653.
Application：WB, Rat, Rat testis.
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Isoform-dependent lysosomal degradation and internalization of Apolipoprotein E requires autophagy proteins.
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