NLRP3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NLRP3 in K-562 cell lysate with NLRP3 polyclonal antibody (Cat # PAB16849) at 1 ug/mL (A) in the absence and (B) in the presence of blocking peptide.
Immunofluorescence
Immunofluorescence staining of human spleen tissue with 20 ug/mL NLRP3 polyclonal antibody (Cat # PAB16849).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NLRP3.
Immunogen
A synthetic peptide corresponding to 16 amino acids near the N-terminus of human NLRP3. The immunogen is located within amino acids 120-170 of NLRP3.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide).
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NLRP3 in K-562 cell lysate with NLRP3 polyclonal antibody (Cat # PAB16849) at 1 ug/mL (A) in the absence and (B) in the presence of blocking peptide.Immunofluorescence
Immunofluorescence staining of human spleen tissue with 20 ug/mL NLRP3 polyclonal antibody (Cat # PAB16849).Enzyme-linked Immunoabsorbent Assay
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Gene Info — NLRP3
Entrez GeneID
114548Protein Accession#
NP_899632Gene Name
NLRP3
Gene Alias
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, FLJ95925, MWS, NALP3, PYPAF1
Gene Description
NLR family, pyrin domain containing 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq
Other Designations
AII/AVP receptor-like|NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3|NACHT, LRR and PYD containing protein 3|OTTHUMP00000038408|OTTHUMP00000038409|OTTHUMP00000038410|PYRIN-containing APAF1-like protein 1|angiotensin/vasopressin receptor
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Interactome
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Disease
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